Endocrine Abstracts

Introduction: Hypopituitary patients with GHD tend to have a reduced exercise capacity. GH is secreted during exercise, has a strong lipolytic action and has been shown to be positively correlated with exercise performance. We hypothesized that the lack of GH leads to a reduced systemic availability of free fatty acids (FFA) during exercise thereby affecting exercise performance.Methods: Patients with GHD and matched sedentary control subjects (CS) were ...

Introduction: Current treatment guidelines for patients with insufficiency of the hypothalamic pituitary adrenal (HPA) axis recommend weight adjusted glucocorticoid supplementation doses to minimize risk of negative side effects (e.g. osteoporosis etc).However, little is known on a potential dose-dependent effect of glucocorticoid supplementation on overall mortality in patients with pituitary disease. Non-functioning pituitary adenoma (NFPA) is one of t...

Introduction: Increased levels of ectopic lipids (IMCL and IHCL) have been related to insulin resistance. Aerobic exercise affects IMCL. GHRT is known to increase exercise capacity, insulin resistance and decrease fat mass. The effect of GHRT on ectopic lipids is not known.Methods: Ten patients with GHD and ten sedentary control subjects (CS; matched for gender, age, BMI and waist) were recruited. VO2max was assessed using an exercise test on ...

Background: Although biochemical diagnosis of endogenous hyperinsulinemic hypoglycemia is straightforward, surgical removal of an insulinoma is hampered by difficulties to localize it using conventional radiological procedures (endosonography, MRI, CT-imaging techniques).In vitro data suggest that human insulinoma cells exhibit a high density of GLP-1R. 111In-exendin-4 is a 111In labeled GLP-1R agonist that binds with high affinity to GLP-1R and m...

Objective: To describe the evolution of neurobehavioral and cognitive symptoms in patients with primary hyperparathyroidism as measured by mini-mental state (MMS), Hamilton’s anxiety and depression scale (HADS) and Clock tests. Scores were also compared with biochemical data.Methods: The Swiss primary hyperparathyroidism (PHPT) Cohort Study is an ongoing, prospective, non-interventional national project collecting clinical, biochemical and outcome d...

Objective: Evaluate cinacalcet use and effect based on follow-up within a cohort study of recently diagnosed Primary Hyperparathyroidism (PHPT) patients. Characteristics, treatment indications and biochemical data are presented with measures of cinacalcet efficacy and safety.Methods: The Swiss Primary Hyperparathyroidism Cohort Study is a prospective, non-interventional project to collect clinical, biochemical and outcome data in patients with PHPT initi...